About

Mark Scrimshire is the Chief Interoperability Officer at Onyx, where he leads the strategy and development of OnyxOS™, a FHIR-native interoperability platform designed to help payers, government agencies, and health tech innovators meet federal mandates and unlock scalable health data exchange. With over 25 years of experience in healthcare technology, Mark is widely recognized as a national leader in digital health transformation and patient-directed interoperability.

Prior to co-founding Onyx, Mark served as the Entrepreneur-in-Residence at the Centers for Medicare & Medicaid Services (CMS), where he architected and launched Blue Button 2.0 - the first FHIR®-based API in U.S. federal healthcare. This groundbreaking initiative enabled over 53 million Medicare beneficiaries to access and share their claims data securely with third-party applications, setting the stage for CMS’s interoperability and patient access regulations.

Mark plays a pivotal role in shaping national data exchange standards. He is the author and lead of the HL7® Da Vinci Payer Data Exchange (PDex) Implementation Guide, which was formally recommended by CMS in its 2024 Interoperability and Prior Authorization Final Rule (CMS-0057-F). He also serves as Co-Chair of the HL7 Financial Management Work Group, driving innovation at the intersection of clinical and administrative data.

In addition, Mark serves on the Board of Directors for the FHIR Business Alliance (FHIRBall) and is an active member of the CARIN Alliance, helping to advance consumer access, data transparency, and ethical interoperability.

Mark’s work continues to bridge policy, technology, and patient empowerment - ensuring that interoperability evolves with purpose, trust, and impact.